论文部分内容阅读
Apelin是孤儿受体APJ的天然配体,apelin/APJ系统对心血管系统的作用主要为:可以通过拮抗血管紧张素Ⅱ的作用而舒张血管降低血压;可以作用于心肌引起强烈的正性肌力作用;在心力衰竭早期表达增加而心力衰竭晚期表达降低,因此,推测apelin/APJ系统可能是防止心力衰竭发生的有效的代偿方式。Apelin/APJ系统还可能参与调节胰腺对胰岛素的分泌,并且该系统还可以促进视网膜毛细血管的增生。Apelin/APJ系统在心血管系统的这些作用提示该系统可能在高血压、糖尿病血管病变、心力衰竭中发挥了一定的作用。
Apelin is an orphan receptor APJ natural ligand, apelin / APJ system on the cardiovascular system mainly as follows: by antagonizing the role of angiotensin Ⅱ and vasodilatory blood pressure; can act on the myocardium caused by a strong positive inotropic Role; early expression of increased heart failure and late expression of reduced heart failure, therefore, speculated that apelin / APJ system may be an effective way to prevent the occurrence of heart failure. The Apelin / APJ system may also be involved in regulating pancreatic insulin secretion, and the system can also promote retinal capillary hyperplasia. These effects of Apelin / APJ system on the cardiovascular system suggest that the system may play a role in hypertension, diabetic angiopathy and heart failure.