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目的探讨胆碱酯酶在肝脏疾病检测中的应用。方法回顾分析本院急慢性肝脏疾病120例患者进行胆碱酯酶检测的临床分析。结果各肝病组与正常组比较P<0.05有显著差异性,有统计学意义。表1可见肝病患者血清CHE活性明显低于正常对照组,且降低程度与肝细胞损害程度相平行。肝病患者CHE活性与ALT无显著相关性。结论通过本组数据各组肝病中CHE活性均明显低于正常对照组(P<0.05),并随肝脏病情程度加重而下降,急性肝炎组ALT升高明显而CHE活性下降较少,说明了急性肝炎肝细胞损伤较重,而肝脏功能较为良好;慢性肝炎组重型肝炎组肝硬化组ALT升高变化不明显,而CHE活性逐渐下降,进一步说明了肝脏合成功能下降,ALT升高变化不明显可能与“胆酶分裂”有关。因此血清胆碱酯酶活力能较好地反映肝脏的合成功能,能准确地反映肝脏的病理损害的程度。
Objective To investigate the application of cholinesterase in the detection of liver diseases. Methods A retrospective analysis of 120 cases of acute and chronic liver disease in our hospital for cholinesterase detection of clinical analysis. Results The liver disease group and the normal group P <0.05 significant difference, with statistical significance. Table 1 shows that patients with liver disease serum CHE activity was significantly lower than the normal control group, and the extent of reduction and liver cell damage in parallel. CHE activity in patients with liver disease and ALT no significant correlation. Conclusions CHE activity in liver disease in each group was significantly lower than that in normal control group (P <0.05), and decreased with the severity of liver disease. ALT increased significantly in acute hepatitis group and decreased less in CHE activity, indicating that acute liver injury Hepatitis hepatocellular injury is more serious, and liver function is better; chronic hepatitis group, severe hepatitis group, cirrhosis ALT increase was not obvious, and CHE activity decreased, further demonstrating the liver synthesis decreased, ALT increase may not be obvious And “bile enzyme division ” related. Therefore, serum cholinesterase activity can better reflect the synthesis of liver function, can accurately reflect the degree of liver pathological damage.