有关新的低渗的离子型和非离子型碘造影剂开发的问题很复杂,由于这些造影剂价格昂贵而限制了临床应用。低渗造影剂(LOCM)是多年来精心研究和发展的产物。这种新技术给病人带来的变化及好处与放射学家有紧密的关系,因此应特别认真地衡量其应用的利与弊。发展史一、离子型化合物儿个重要的历史性发展预示了新的LOCM 的开发,即Swick 博士最初发明的水溶性X 线造影剂及Almén 开发的低渗非离子型造影剂。正象我们应特别感谢Hickey 博士的许多最基本的X 线观察及X 线名词的命名一样,我们应特别感谢 The problems associated with the development of new hypotonic ionic and non-ionic iodine contrast agents are complex and their clinical application is limited by the high cost of these contrast agents. Low-permeability contrast media (LOCM) is a product of years of careful research and development. The changes and benefits that this new technology brings to patients have a close relationship with radiologists, so the pros and cons of their applications should be carefully measured. A History of Development One of the most important historic developments in ionic compounds foreshadows the development of a new LOCM, a water-soluble X-ray contrast agent originally invented by Dr. Swick and a hypotonic non-ionic contrast agent developed by Almén. Just as we should especially thank Dr. Hickey for many of the most basic X-ray observations and the naming of X-rated nouns, we should be particularly grateful