锂盐是治疗情感性精神病的重要药物,但安全范围窄,锂中毒与红细胞中锂的浓度有关。因此,测定数据是否准确,将影响诊断,也是造成目前文献上大量资料相互矛盾的原因。本文建立了红细胞分离、取样及消化等一整套准确的样品预处理方法,并用原子吸收分光光度法测得红细胞及血浆中锂的浓度。结果测得红细胞锂的回收率为94.6％～103.0％,标准偏差为0.015,变异系数为0.024,获得较满意的结果。 Lithium salt is an important drug for the treatment of emotional psychosis, but the safety margin is narrow, lithium poisoning and the concentration of lithium in red blood cells. Therefore, the determination of data is accurate, will affect the diagnosis, but also contributed to the current literature on a large number of conflicting reasons. In this paper, a set of accurate sample pretreatment methods such as separation, sampling and digestion of erythrocytes were established. The concentrations of lithium in erythrocytes and plasma were measured by atomic absorption spectrophotometry. The results showed that the recoveries of lithium in erythrocytes were 94.6% ~ 103.0%, the standard deviation was 0.015 and the coefficient of variation was 0.024. Satisfactory results were obtained.