Stabilization of estimated glomerular filtration rate in kidney transplantation from deceased donors

来源 :World Journal of Transplantation | 被引量 : 0次 | 上传用户:xdz429
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
AIM To evaluate and compare the outcomes of kidney transplant(KT) from deceased donors among standard criteria, acute kidney injury(AKI) and expanded criteria donors(ECDs). METHODS This retrospective study included 111 deceased donor kidney transplant recipients(DDKT). Deceased donors were classified as standard criteria donor(SCD), AKI donor and ECD. AKI was diagnosed and classified based on change of serum Cr by acute kidney injury network(AKIN) criteria. Primary outcome was one-year estimated glomerular filtration rate(eG FR) calculated from Cr by CKD-EPI. Multivariate regression analysis was done by adjusting factors such as type of DDKT, %Panel-reactive antibodies, cold ischemic time, the presence of delayed graft function and the use of induction therapy. Significantfactors that can affect the primary outcomes were then identified. RESULTS ECD group had a significantly lower eG FR at one year(33.9 ± 17.3 mL /min) when compared with AKI group(56.6 ± 23.9) and SCD group(63.6 ± 19.9)(P < 0.001). For AKI group, one-year eG FR was also indifferent among AKIN stage 1, 2 or 3. Patients with AKIN stage 3 had progressive increase of eG FR from 49.6 ± 27.2 at discharge to 61.9 ± 29.0 mL /min at one year. From Kaplan-Meier analysis, AKI donor showed better two-year graft survival than ECD(100% vs 88.5%, P = 0.006). Interestingly, AKI group had a stable eG FR at one and two year. The two-year eG FR of AKI group was not significantly different from SCD group(56.6 ± 24.5 mL /min vs 58.6 ± 23.2 mL /min, P = 0.65). CONCLUSION Kidney transplantations from deceased donors with variable stage of acute kidney injuries were associated with favorable two-year allograft function. The outcomes were comparable with KT from SCD. This information supports the option that deceased donors with AKI are an important source of organ for kidney transplantation even in the presence of stage 3 AKI. AIM To evaluate and compare the outcomes of kidney transplant (KT) from deceased donors among standard criteria, acute kidney injury (AKI) and expanded criteria donors (ECDs). METHODS This retrospective study included 111 deceased donors kidney transplant recipients (DDKT). Deceased AKI was diagnosed and classified based on change of serum Cr by acute kidney injury network (AKIN) criteria. Primary outcome was one-year estimated glomerular filtration rate (eG FR ) calculated from Cr by CKD-EPI. Multivariate regression analysis was done by adjusting factors such as type of DDKT,% Panel-reactive antibodies, cold ischemic time, the presence of delayed graft function and the use of induction therapy. Significantfactors that can affect RESULTS The ECD group had a significantly lower eG FR at one year (33.9 ± 17.3 mL / min) when compared with the AKI group (56.6 ± 23.9) and the SCD group (63.6 ± 1 9.9) (P <0.001). For AKI group, one-year eG FR was also indifferent among AKIN stages 1, 2 or 3. Patients with AKIN stage 3 had progressive increase of eG FR from 49.6 ± 27.2 at discharge to 61.9 ± 29.0 From Kaplan-Meier analysis, AKI donor showed better two-year graft survival than ECD (100% vs 88.5%, P = 0.006). Interestingly, AKI group had a stable eG FR at one and two year . The two-year eG FR of AKI group was not significantly different from SCD group (56.6 ± 24.5 mL / min vs 58.6 ± 23.2 mL / min, P = 0.65). CONCLUSION Kidney transplantations from deceased donors with variable stage of acute kidney injuries The findings were comparable with KT from SCD. This information supports the option that deceased donors with AKI are an important source of organ for kidney transplantation even in the presence of stage 3 AKI.
其他文献
俭朴,即俭省朴素,它与奢侈相对,是一切美德风尚之源、精神生活之本。企业是国家经济创造的承担者,它的成长与国家的未来息息相关。因为俭朴,人就不会生贪欲之心;因为俭朴,企业就不会
报纸
1走进水的世界,无法知晓彼岸的归期。撬动旅途中羁绊的礁石,我们在某个夜晚、某个语词中开始逐渐成熟。风行水中,我们用手指和嘴唇餐风露宿,在失去语言表达的意境中生死相拥
漫天的风雪中,我们迎来了早已注定不会平凡的2008年,但是,或许所有人都没有想到,从雪灾到地震到奥运,这个被深深地打上了奥运烙印的一年会在中国人的记忆中留下如此多的不同
Shanghai cuisine has attracted the world’s attention in recent years, as has the city’s rapid growth and development. This book contains recipes for 20 typica
小说《人生》的主人公高加林是一个生活在80年代农村的知识青年,他原本是一个幸福的人,他有理想、有追求、有才华。但是他在人生的旅程中逐渐偏离了生活的轨迹,迷失了自己,对
妈妈常常在我耳边唠叨,说我小时候那么乖巧听话,不知道为什么现在变得这么调皮。她还拿出我5岁时候的照片来作证。照片上的我梳着小羊角辫。穿着胸前有蝴蝶结的连衣裙,清秀乖巧得一点不像我。  别的女孩子在我这个年纪,都喜欢穿裙子,留长头发,将自己打扮得漂漂亮亮的。我却从来都是短头发,说话做事都是大大咧咧。妈妈费尽心思想把我培养成小淑女,天天在我耳边提醒:女孩子家要站有站相,坐有坐相;吃饭的时候要秀气,不能
期刊
解码博士:我读高三了,有种厌学的感觉,想出去打工半年再去转读技校,但又不知读什么专业,希望你能给我一些建议,让我走出困境。 Decoding Dr.: When I was a senior 3 studen
一次考试,对于学生来说不仅是检查学习的效果,而且也是对心灵的考验。 An exam is not only an examination of the effect of learning, but also a test of the soul.
期刊
语文月考成绩出来了,当我翻阅学生试卷时,意外地发现我们班的小君竟破天荒地考了68分。该生语文成绩特差,每次考试都在四五十分之间。我曾严厉批评过他,也曾找他谈 The resu
禅宗语:百尺竿头更进一步。这就是说,绝对的高度一定在竿子的丈量范围以外——也就是在竿头之上。所以,只有超越竿子,更进一步,才有可能达到绝对高度。同样的道理,绝对自由,