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目的应用荧光原位杂交技术对胚胎停育患者绒毛组织进行染色体数目分析,探讨染色体数目异常与胚胎停育的关系,查找胚胎停育的原因。方法选择13、16、18、21、22、X、Y染色体的荧光DNA探针,对145例胚胎停育组织的绒毛样本染色体数目进行检测,分析胚胎停育患者绒毛染色体数目异常情况。结果 145例绒毛组织全部检测成功,共检出异常绒毛组织55例,其中染色体三体32例;染色体单体14例;多倍体7例;嵌合体2例。结论染色体数目异常是胚胎停育的重要原因,其中染色体三体和单体最多见。
Objective To analyze the chromosome number of villi in patients with embryo stop by fluorescence in situ hybridization (FISH) technique, and to explore the relationship between the number of abnormal chromosomes and the suspension of embryos and to find out the reasons for the suspension of embryos. Methods Fluorescent DNA probes of 13, 16, 18, 21, 22, X and Y chromosomes were selected to detect the number of chromosomes in the villi of 145 cases of embryo offspring. The number of chromosome abnormalities in the patients with embryo implantation was analyzed. Results 145 cases of villi were detected successfully. 55 cases of abnormal villi were detected, including 32 cases of trisomy, 14 cases of chromosome, 7 cases of polyploid and 2 cases of chimerism. Conclusion Abnormal number of chromosomes is an important reason for embryo stop, of which chromosome trisomies and monomers are the most common.