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以反相高效液相色谱内标定量法对6名原发性高血压志愿受试者口服尼群地平0.5mg/kg进行药物动力学和药效学研究。血药浓度-时间曲线为二室开放模型;药动学参数:Ka=0.71±0.15h~(-1),T_(max)=1.5h,C_(max)=67ng/mL。血药浓度与血压下降明显相关(r=-0.819);最大作用维持时间为2-6h。
The pharmacokinetics and pharmacodynamics of nitrendipine 0.5 mg / kg in 6 volunteers of essential hypertension were studied by reverse-phase high performance liquid chromatography with internal standard quantification. The plasma concentration-time curve was a two-compartment open model. Pharmacokinetic parameters were Ka = 0.71 ± 0.15 h -1, T max = 1.5 h and C max = 67 ng / mL. Plasma concentration and blood pressure decreased significantly (r = -0.819); the maximum effect of maintenance time is 2-6h.