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本文对亚急性铅中毒大鼠尿激肽释放酶排泄量进行了研究。发现血铅与尿Ka高度相关,大鼠染毒2、3个月尿Ka随血铅水平增高而增高,与对照组比较差异显著。染毒1个月停毒1个月尿Ka略有回降,染毒3个月停毒1个月尿Ka不能恢复,这与血铅水平、病理改变相一致。提示测定尿中Ka含量可直接反映肾内水平.间接反映肾铅水平。该指标较为敏感,无损伤,可考虑作为铅中毒肾损害血压改变的监护指标。
In this paper, subacute lead poisoning rats urinary kallikrein excretion was studied. Blood lead levels were found to be highly correlated with urine Ka. Urine Ka increased with blood lead levels at 2 and 3 months after exposure in rats, which was significantly different from the control group. One month after exposure to detoxification, urinary Ka decreased slightly in one month. After three months of detoxification, urinary Ka could not be recovered for one month, which was consistent with blood lead levels and pathological changes. Prompt determination of urinary Ka content can directly reflect the level of kidney, indirectly reflect the level of renal lead. The index is more sensitive, no damage, can be considered as lead poisoning kidney damage blood pressure monitoring of indicators of change.