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[性状] 本品为黄色结晶和结晶性粉末,无臭无味或稍有特殊气味。本品易溶于氯仿或冰醋酸,稍不易溶于丙酮、醋酸乙酯或苯,难溶于甲醇、乙醇或己烷,几乎不溶于水, [作用] 本品为抗高血压药物。动物实验表明,在各种高血压大白鼠及肾性高血压狗,均在3小时以后出现最大下降值,在大白鼠24小时,狗6～10小时仍维持继续下降。与对照药肼苯哒嗪比较,本品出现最大下降的时间较长,恢复比较缓慢,对正常血压动物则无降压作用。另外发现本药出现抗高血压作用时对心跳数的影响比肼苯哒嗪小,本药的降压机理是由于抑制血管的收缩,减少末梢血管的阻
[Characters] This product is yellow crystalline and crystalline powder, odorless or slightly odorless. This product is soluble in chloroform or glacial acetic acid, slightly soluble in acetone, ethyl acetate or benzene, insoluble in methanol, ethanol or hexane, almost insoluble in water, [role] This product is anti-hypertensive drugs. Animal experiments show that in a variety of hypertensive rats and renal hypertensive dogs, the maximum decline occurred after 3 hours in rats 24 hours, the dog 6 to 10 hours still continued to decline. Compared with the control drug hydralazine, the product showed a maximum decline for a long time, recovery is relatively slow, there is no antihypertensive effect on normal blood pressure animals. Also found that the drug appears antihypertensive effect on the number of heartbeats than hydralazine small, the drug’s antihypertensive mechanism is due to inhibition of vascular contraction and reduce the resistance of peripheral blood vessels