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目的:研究冠心病(CHD)患者肾上腺髓质素前体N端20肽(PAMP)浓度在冠状动脉循环过程中的变化。方法:用放射免疫方法分别测定冠心病患者(冠心病组)与对照组外周、冠状静脉窦与主动脉根部血浆中PAMP浓度。结果:冠心病组外周、冠状静脉窦与主动脉根部血浆中PAMP浓度均明显增高,与对照组比较均差异有统计学意义(P<0.01),冠心病组冠状静脉窦PAMP水平与主动脉根部及外周血浆中PAMP浓度比较均有统计学意义(P<0.01)。结论:PAMP参与了冠心病的病理生理过程,可能是机体对维持内环境稳态的一种自我保护机制,在冠心病的病程发展过程中有可能是一种较为重要的血管活性物质。
Objective: To study the changes of N-terminal 20 peptide (PAMP) of adrenomedullin precursor during coronary circulation in patients with coronary heart disease (CHD). Methods: The plasma concentrations of PAMP in the peripheral, coronary sinus and aortic root were measured by radioimmunoassay in patients with coronary heart disease (CHD) and control group respectively. Results: The concentrations of PAMP in the plasma of the coronary sinus and the aortic root were significantly increased in the coronary heart disease group compared with the control group (P <0.01). The level of PAMP in the coronary sinus and the aortic root And peripheral plasma PAMP concentrations were statistically significant (P <0.01). CONCLUSION: PAMP participates in the pathophysiological process of coronary heart disease, which may be a self-protection mechanism for the homeostasis of the internal environment. PAMP may be a more important vasoactive substance during the development of coronary heart disease.