早产儿脑白质损伤(white matter damage,WMD),指24~35周出生的早产未熟儿由血管损伤和炎症反应而致的大脑白质病变,是早产儿最常见的脑损伤形式。19世纪中叶Parrot和Virchow等首先记载了本症,1962年Banker和Larroche又对本症做了详细报道,确定了PVL的概念[1]。该病是导致早产儿 White matter damage (WMD) in preterm infants is defined as the most common form of brain damage in preterm infants, premature infants born 24 to 35 weeks old with infantile white matter lesions caused by vascular injury and inflammation. Parrot and Virchow first documented the disease in the mid-19th century. In 1962, Banker and Larroche reported on the disease in detail and determined the concept of PVL [1]. The disease is caused by premature babies