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目的:研究血管紧张素转化酶抑制剂卡托普利治疗高血压合并冠心病的疗效。方法:收集了在我院就诊的高血压合并冠心病患者的临床资料,观察治疗后心绞痛症状的缓解情况、心电图检查的改变情况以及24h平均血压的变化情况,并用SPSS18.0软件进行统计学分析。结果:治疗组的临床症状疗效、心电图检查疗效均明显好于对照组(P<0.05),并且在治疗后24h平均血压明显降低(P<0.05)。结论:血管紧张素转化酶抑制剂卡托普利能够扩张冠脉血管、降低外周阻力和心肌做功、抑制心肌重构,对于改善高血压合并冠心病患者的临床症状和心电图情况的效果明显好于传统的硝酸甘油,值得在临床中推广使用。
Objective: To investigate the curative effect of captopril, an angiotensin converting enzyme inhibitor, on hypertension and coronary heart disease. Methods: The clinical data of hypertensive patients with coronary heart disease (CHD) treated in our hospital were collected. The relief of angina pectoris after treatment, the change of ECG and the change of mean blood pressure 24h were observed and analyzed by SPSS18.0 software . Results: The efficacy of clinical symptoms and electrocardiogram in the treatment group were significantly better than those in the control group (P <0.05), and mean blood pressure was significantly lower at 24h after treatment (P <0.05). Conclusion: Captopril, an angiotensin converting enzyme inhibitor, can dilate coronary arteries, reduce peripheral resistance and cardiac work, inhibit myocardial remodeling, and improve the clinical symptoms and ECG of hypertensive patients with coronary heart disease Traditional nitroglycerin, it is worth promoting in clinical use.