整合素是一类跨细胞膜的糖蛋白细胞表面受体家族分子。在正常肾脏的实质及间质细胞中均有整合素的表达 ,在病变肾脏中 ,整合素有种类和数量的改变。在肾纤维化发生过程中肾间质炎症细胞浸润、成纤维细胞激活、细胞外基质过分沉积等均与整合素异常表达有关。对整合素与肾纤维关系的深入研究 ,有可能为肾纤维化的诊断与防治带来新的希望。 Integrins are a family of glycoprotein cell-surface receptor family molecules that cross cell membranes. In the normal kidney stroma and interstitial cells have integrin expression in the diseased kidneys, integrins have the type and number of changes. In the process of renal fibrosis, interstitial inflammatory cell infiltration, fibroblast activation, excessive extracellular matrix deposition and integrin abnormal expression. In-depth study of the relationship between integrin and renal fibers may bring new hope for the diagnosis and prevention of renal fibrosis.