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目的系统评价中国居民高尿酸血症的危险因素,为预防控制决策提供依据。方法应用Meta分析方法,对我国2000—2008年间公开发表的有关高尿酸血症危险因素病例-对照研究的10篇文献资料进行定量综合分析;运用ReviewManager4.2进行一致性检验,并且进行合并OR值和95%CI的计算。结果各因素合并OR值分别为:体质指数OR=3.09(95%CI:1.08～8.83);高甘油三酯OR=2.19(95%CI:1.45～3.30);肥胖OR=1.91(95%CI:1.63～2.24);饮酒OR=1.85(95%CI:1.42～2.43);高血糖OR=1.38(95%CI:1.16～1.65);高血压OR=1.20(95%CI:1.03～1.39)。结论高尿酸血症发生的可能主要危险因素为体质指数、高甘油三酯、肥胖、饮酒、高血糖、高血压。
Objective To systematically evaluate the risk factors of hyperuricemia in Chinese residents and provide the basis for prevention and control decision-making. Methods Meta-analysis was used to analyze the 10 published case-control studies of risk factors for hyperuricemia in China from 2000 to 2008. The data were analyzed by using ReviewManager 4.2 and the OR values And 95% CI calculation. Results The combined OR of all factors were as follows: body mass index (OR) = 3.09 (95% CI: 1.08-8.83); high triglyceride OR = 2.19 (95% CI: 1.45-3.30); obesity OR = 1.91 (95% CI: 1.42-2.43); high blood sugar OR = 1.38 (95% CI: 1.16-1.65); high blood pressure OR = 1.20 (95% CI: 1.03-1.39). Conclusions The main risk factors of hyperuricemia are body mass index, high triglyceride, obesity, alcohol consumption, hyperglycemia and hypertension.