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从苯接触工人的培养淋巴细胞和苯接触的大鼠、兔的骨髓细胞中,观察到染色体畸变率增高。当前,业已提出以姊妹染色单体互换的鉴定作为估计环境化学物诱变作用的一种非常灵敏的方法。此法也有利于细胞周期动力学的研究。目前,除染色体畸变和姊妹染色单体互换率外,另外也有采用姊妹染色单体不同的染色法,做为苯接触工人的培养淋巴细胞动力学上的检测。一、受试者:16名女工,33～63岁,在小型陶瓷厂从事陶器涂漆,根据过去接触程
Chromosome aberration rates were observed to be elevated in benzene-exposed workers’ lymphocytes and benzene-contacted rats and rabbit bone marrow cells. Currently, the identification of sister chromatid exchanges has been proposed as a very sensitive method of estimating the mutagenic effects of environmental chemicals. This method is also conducive to cell cycle kinetics. At present, in addition to chromosomal aberrations and sister chromatid exchange rates, there are also different staining methods using sister chromatids, as benzene-exposed workers in cultured lymphocyte kinetics. First, the subjects: 16 female workers, 33 to 63 years old, engaged in pottery in small ceramics factory paint, according to the past contact process