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目的：探讨脊髓缺血再灌注损伤中体感诱发电位的变化规律及其对神经功能的监测作用。方法新西兰大白兔26只，采用肾下腹主动脉阻断45 min，建立脊髓缺血再灌注模型。分别于缺血前后及再灌注后不同时间监测SEP变化。再灌注24 h和48 h进行神经功能评分。结果缺血5 min时P1潜伏期SEPs显著增长，差异有统计学意义（P＜0.05），缺血8 min时P1波幅显著降低，差异有统计学意义（P＜0.05）。SEPs波形缺血10 min时不存在。SEPs波形在再灌注后10 min得到恢复，P1潜伏期显著增加，差异有统计学意义（P＜0.05）。P1波幅再灌注15 min时变为缺血前状态，差异无统计学意义（P＞0.05）。再灌注30 min后P1潜伏期不同时间点逐渐恢复；24 h和48 h再灌注P1波幅再次降低。24 h和48 h再灌注神经功能评分出现上升，差异有统计学意义（P＜0.05）。结论 SEPs监测可以作为判断神经功能预后的可靠指标。“,”Objective To investigate the changes of somatosensory evoked potentials in spinal cord ischemia reperfusion injury and its effect on the monitoring of neurological function.Methods26 New Zealand white rabbits by infrarenal abdominal aorta occlusion for 45 minutes,the model of spinal cord ischemia / reperfusion respectively. Before and after ischemia and re perfusion after different time monitoring of SEP changes.Reperfusion for 24 and 48 h were nerve function score.ResultsIn 5 minutes SEPs P1 latency was signifi cantly prolonged.the amplitude of P1 in ischemia 8 minutes signifi cantly decreased.SEPs waveforms disappeared 10 minutes of ischemia.SEPs waveforms recovered 10 min after reperfusion,P1 latency was signifi cantly prolonged.Reperfusion 15 min P1 wave amplitude recovered to before ischemia.Reperfusion after 30 minutes at each time point P1 latency was recovery trend;then reperfusion for 24 and 48 h P1 amplitude decreased again.Reperfusion for 24 and 48 hours neural function score gradually increased.ConclusionSEPs monitoring can be used as a reliable indicator to judge the prognosis of neurological function.