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目的:探讨早产儿暂时性低甲状腺素血症与胎龄及出生体重间的关系。方法:选择早产儿180例,按照胎龄分为A1组28例、A2组34例、A3组58例、A4组60例,按照出生体重分为B1组10例、B2组60例、B3组72例、B4组38例。另外,根据早产儿血清T4<77nmol/L,TSH<20mU/L分为暂时性低甲状腺素血症(THOP)组55例,正常组125例。采用电化学发光免疫法测定早产儿血清三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、甲状腺素(T4)、游离甲状腺素(FT4)和促甲状腺素(TSH)水平,并详细记录早产儿胎龄、出生体重、规律排便时间、高胆红素血症持续时间、静脉营养时间及住院时间等。结果:A1组THOP发生率为75.0%,非常显著高于A2组的47.1%、A3组的20.7%和A4组的10.0%(P<0.01);A2组THOP发生率非常显著高A3与A4组(P<0.01);A3、A4组THOP发生率差异不显著(P>0.05)。B1组THOP发生率为80.0%,非常显著高于B2组的48.3%、B3组的16.7%和B4组的10.5%(P<0.01);B2组THOP发生率非常显著高B3与B4组(P<0.01);B3、B4组THOP发生率差异不显著(P>0.05)。THOP组规律排便时间、高胆红素血症持续时间、静脉营养时间和住院时间均显著长于正常组(P<0.05)。结论:早产儿THOP发生率与胎龄和出生体重密切相关。
Objective: To investigate the relationship between transient hypothyroxinemia and gestational age and birth weight in premature infants. Methods: One hundred and eighty premature infants were selected and divided into A1 group (28 cases), A2 group (34 cases), A3 group (58 cases) and A4 group (60 cases). According to birth weight, 10 cases were divided into B1 group, 72 cases, B4 group 38 cases. In addition, according to preterm infant serum T4 <77nmol / L, TSH <20mU / L was divided into temporary hypothyroxinemia (THOP) group of 55 cases, the normal group of 125 cases. Serum triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4), free thyroxine (FT4) and thyrotropin (TSH) were measured by electrochemiluminescence immunoassay Level, and detailed records of gestational age of preterm children, birth weight, regular bowel movements, duration of hyperbilirubinemia, intravenous nutrition and hospital stay. Results: The THOP incidence in group A1 was 75.0%, significantly higher than that in group A2 47.1%, group A3 20.7% and group A4 10.0% (P <0.01). The incidence of THOP in group A2 was significantly higher than those in group A3 and A4 (P <0.01). There was no significant difference in the incidence of THOP between A3 and A4 (P> 0.05). The prevalence of THOP in group B1 was 80.0%, significantly higher than that in group B2 48.3%, group B3 16.7% and group B4 10.5% (P <0.01) <0.01). There was no significant difference in the incidence of THOP between groups B3 and B4 (P> 0.05). The regular duration of defecation, duration of hyperbilirubinemia, duration of intravenous nutrition and hospital stay in THOP group were significantly longer than those in normal group (P <0.05). Conclusion: The prevalence of THOP in preterm infants is closely related to gestational age and birth weight.