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作者评价了水飞蓟素及其主要成分水飞蓟宾对高胆固醇饲料(HCD)诱导的大鼠血胆固醇过多症的影响,分析了血浆脂蛋白及肝中胆固醇(C)的水平,并用具有抗氧化的降胆固醇药普罗布考(probucob)作阳性对照,比较血清中的胆固醇的水平。雌性 Wistar 大鼠自由饮水并给以标准实验室饲料,或给以含1%胆固醇+10%猪油的 HCD,剂量相关实验则添加0.1%、0.5%、1.0%的水飞蓟素或普罗布考。由每餐的饲料摄入量计算相应的水飞蓟素[mg/100
The authors evaluated the effects of silymarin and its main component, silybin, on hypercholesterolemic rats induced by high cholesterol diet (HCD), and analyzed plasma lipoprotein levels and hepatic cholesterol (C) levels and used antioxidants. The cholesterol-lowering drug probucob was used as a positive control to compare serum cholesterol levels. Female Wistar rats were given free access to water and given standard laboratory diets, or HCD supplemented with 1% cholesterol + 10% lard, and 0.1%, 0.5%, 1.0% silymarin or probucol dose-dependent experiments. The corresponding silymarin is calculated from the feed intake of each meal [mg/100