胰腺癌仍是威胁健康的重要医学问题。在过去的10年中,有研究发现生长抑素及其类似物对受体表达阳性的正常和肿瘤细胞具有抗增殖作用。生长抑素及其类似物通过生长抑素受体发挥作用,而受体有5种亚型,其在正常或肿瘤细胞的表达是各不相同的。本文作者综述生长抑素及其类似物抗增殖活性的生物学机制方面的进展。 Pancreatic cancer is still an important medical problem that threatens health. In the past 10 years, studies have found that somatostatin and its analogs have antiproliferative effects on normal and tumor cells with receptor expression. Somatostatin and its analogues act through the somatostatin receptor, while the receptor has five subtypes whose expression varies in normal or tumor cells. The authors review the advances in the biological mechanisms of antiproliferative activity of somatostatin and its analogues.