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microRNAs(miRNAs)是一类转录后调控基因表达的内源性非编码微小RNA。愈来愈多的研究显示,miRNAs在肿瘤免疫应答中发挥重要调控作用。一方面,miRNAs通过转录后调控ICAM(intercellularadhesion molecule)、B7(CD80/86)和HLA-G(human leucocyte antigen-G)等肿瘤表面分子的表达,影响肿瘤的免疫原性;另一方面,miRNAs通过平衡肿瘤局部的细胞因子微环境或调控肿瘤免疫相关细胞的分化、发育及功能发挥,调节机体抗肿瘤免疫应答。为后续深入研究肿瘤与宿主的相互作用机制,以及发展更有效的肿瘤生物治疗手段,就目前miRNAs在肿瘤免疫中的调控作用的研究进展做一综述。
MicroRNAs (miRNAs) are a class of endogenous non-coding microRNAs that regulate post-transcriptional gene expression. More and more studies have shown that miRNAs play an important regulatory role in tumor immune response. On the one hand, miRNAs affect the tumor immunogenicity through the expression of tumor surface molecules such as intercellularadhesion molecule (ICAM), B7 (CD80 / 86) and HLA-G. On the other hand, miRNAs By regulating the local tumor cell cytokines microenvironment or regulating the differentiation, development and function of tumor-related immune cells, regulating the body’s anti-tumor immune response. In order to further study the mechanism of tumor-host interaction and to develop more effective means of tumor biotherapy, the current research progress on the regulation of miRNAs in tumor immunity is reviewed.