人的一生不断进行着骨的新陈代谢。这是通过旧骨吸收和新骨形成来完成。在正常人两者紧密偶联,假如两者失偶联会引起骨量、骨结构和骨强度的改变。但体内骨结构和骨强度很难被检测。近代通过测定骨转换生化标志物了解是否存在骨代谢的失衡。文章介绍骨形成和骨吸收的生化标志物及其临床应用,由于无创伤,价较廉,正被推广应用。 People’s lives continue to carry the bone metabolism. This is done through the absorption of old bone and new bone formation. In normal close coupling between the two, if the loss of couple the two will lead to changes in bone mass, bone structure and bone strength. However, in vivo bone structure and bone strength are difficult to detect. Modern biochemical markers of bone turnover by measuring the existence of bone metabolism imbalance exists. The article describes the biochemical markers of bone formation and bone resorption and its clinical application, due to non-invasive, inexpensive, is being promoted.