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目的 研究婴幼儿接种国产BRDⅡ株风疹减毒活疫苗后的免疫持久性。方法 以血凝抑制 (HI)抗体方法 ,选择城区既往无风疹感染和风疹疫苗免疫史的 6～ 18月龄组婴幼儿 ,对其接种风疹疫苗 1年和 2年后的抗体水平进行检测。结果 在 6、7、8、9、12和 18月龄组初免获得成功的儿童中 ,接种风疹疫苗 1年和 2年后 ,各组HI抗体阳性率仍分别高达 94.44 %、97.2 2 %、96 .6 7%、10 0 .0 0 %、10 0 .0 0 %、10 0 .0 0 %和 93.10 %、93.5 5 %、96 .77%、 96 .97%、10 0 .0 0 %、10 0 .0 0 % (P >0 .0 5 ) ,但免后 1年和 2年的GMRTs则分别较免后 1个月和免后 1年约降低了 5 0 % ,且免后 2年 6～7月龄组的GMRTs(2 9.89)显著低于 8～ 18月龄组 (5 3.0 0 )的结果 (t =3.5 8,P <0 .0 0 1)。结论 国产风疹疫苗起始免疫月龄不宜太小 ,以儿童出生后 8月龄为宜 ,加强免疫的时间可暂时参考国外目前已实行的免疫方案
Objective To study the immunocompetence of infants and young children vaccinated with live attenuated BRU strain BRDⅡ. Methods HI antibody was used to select infants aged 6 ~ 18 months with no history of rubella infection and rubella vaccine in urban area. The antibody levels of rubella vaccine at 1 year and 2 years after rubella vaccination were tested. Results The positive rate of HI antibody in each group was 94.44% and 97.22% respectively after 1 year and 2 years of immunization with rubella vaccine in 6, 7, 8, 9, 12 and 18 months old group, 96.6%, 10.00%, 10.0%, 10.0% and 93.10%, 93.5%, 96.77%, 96.97%, 100.0% , 100.0% (P> 0.05), but the GMRTs of 1 year and 2 years after immunization were reduced by about 50% compared with 1 month after immunization and 1 year after immunization, respectively The GMRTs (2 9.89) in the 6-7 month group were significantly lower than those in the 8-18 month group (5.300) (t = 3.58, P <0.01). Conclusion The initial age of domestic rubella vaccine should not be too small, the age of 8 months after child birth is appropriate, to strengthen the immunization time can temporarily refer to the current foreign immunization program