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目的探讨男性血清尿酸水平与心房颤动患病率的相关性。方法根据对80 006名男性的调查资料,将调查对象依据血清尿酸水平四分位,用Logistic回归分析血清尿酸水平与房颤患病率的相关性,得出在校正了已知房颤相关危险因素后的OR(odds ratio)值。结果在被调查的人群中,血清尿酸四分位心房颤动的患病率分别是0.21%、0.33%、0.58%和0.86%,在校正了年龄、收缩压(SBP)、舒张压(DBP)、体质指数(BMI)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)和C-反应蛋白(hs-CRP)、吸烟、饮酒和相关疾病史之后,四分位中第2、3、4分位的OR值分别比第1分位的增高1.61、2.78、3.41倍。结论高血清尿酸水平人群的心房纤颤患病率较高,高血清尿酸水平与心房纤颤独立相关。
Objective To investigate the correlation between serum uric acid level and the prevalence of atrial fibrillation in men. Methods According to the survey data of 80 006 men, the subjects were based on the serum uric acid level quartiles, Logistic regression analysis of the correlation between serum uric acid levels and the prevalence of atrial fibrillation, obtained in correcting the known risk of atrial fibrillation OR (odds ratio) value after the factor. Results The prevalence of serum uric acid quartile atrial fibrillation was 0.21%, 0.33%, 0.58%, and 0.86%, respectively, in the surveyed population, with age, systolic blood pressure (SBP), diastolic blood pressure Body mass index (BMI), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG) (Hs-CRP), smoking, drinking and related disease history, the OR of the second, third and fourth quartiles in the quartile were 1.61, 2.78 and 3.41 times higher than that of the first quartile. Conclusions The prevalence of atrial fibrillation is high in people with high serum uric acid level, and the serum uric acid level is independently associated with atrial fibrillation.