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近年来抗菌素虽已得到普遍应用,但由于有时能引致过敏反应以及细菌抗药性的产生,它们在临床上并不能完全取代磺胺类药物的地位,而是起着相互补充的作用。直到不久以前,常用的磺胺类药物如磺胺噻唑和磺胺嘧啶等有一个共同缺点,就是较易从体内排出,因而在一个疗程中必须按时经常服用,以维持其在血液中的有效浓度。例如一般在第一次服2克,以后就须要不分昼夜地每4小时服用1克,这种服用方法自然给病人带来很大麻烦。硫胺甲基嘧啶和磺胺二甲嘧啶在这方面虽然有所改进,但差别不大。为此,近年来在长效磺胺药物的寻找方面作了许多研究工作,而磺胺
Although antibiotics have been widely used in recent years, they can not completely replace the status of sulfa drugs because they can sometimes cause allergic reactions and bacterial resistance. They play a complementary role. Until recently, the commonly used sulfonamides, such as sulfathiazole and sulfadiazine, had a common disadvantage that they were easily excreted from the body and therefore must be taken regularly and regularly over a course of treatment to maintain their effective concentration in the bloodstream. For example, the first general service 2 grams, after all day and night to take 1 gram every 4 hours, this method of taking patients naturally bring a lot of trouble. Thiram methyl pyrimidine and sulfamethazine in this area although improved, but not very different. To this end, in recent years in search of long-acting sulfa drugs made a lot of research work, and sulfa