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目的 探讨静脉注射尼群地平对肺缺血再灌注后血栓素A2 (TXA2 )和前列环素(PGI2 )变化的影响。方法 用大鼠在体肺温缺血再灌注模型和放免法检测缺血再灌注肺血栓素B2 (TXB2 )、6-酮 -前列腺素F1α(6-Keto-PGF1α)含量 ,同时行病理学检查。结果 药物治疗显著降低了TXB2 含量 (P <0 .0 1) ,使 6-Keto -PGF1α含量和 6-Keto -PGF1α TXB2 比值升高 (P <0 .0 1)。并减轻了肺缺血再灌注损伤程度。结论 静脉注射尼群地平治疗具有防止缺血再灌注肺TXA2 PGI2 平衡紊乱作用 ,可改善血流 ,从而减轻肺缺血再灌注损伤。
Objective To investigate the effect of intravenous nitrendipine on the changes of thromboxane A2 (TXA2) and prostacyclin (PGI2) after pulmonary ischemia-reperfusion in rats. Methods The contents of TXB2 and 6-Keto-PGF1α in ischemia-reperfusion rats were detected by radioimmunoassay and radioimmunoassay in rats. Pathological examination . Results The drug treatment significantly reduced the level of TXB2 (P <0.01), and increased the content of 6-Keto-PGF1α and the ratio of 6-Keto-PGF1α TXB2 (P <0.01). And reduce the degree of lung ischemia-reperfusion injury. Conclusion Intravenous injection of nitrendipine can prevent the imbalance of TXA2 PGI2 from ischemia-reperfusion injury, improve the blood flow and relieve the lung ischemia-reperfusion injury.