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目的:研究复方甘草酸苷对佐剂性关节炎大鼠血清中TNF-αIL-1和IL-6表达水平的影响,以探讨复方甘草酸苷对佐剂性关节炎的治疗作用。方法:通过给大鼠右后足跖部皮下注射完全弗氏佐剂(CFA)建立类风湿性关节炎的动物模型(AA),在致炎后第14d,大鼠继发性关节炎出现。开始在治疗组AA大鼠腹腔注射复方甘草酸苷注射液2mg/kg,连续10d,直至第28d处死全部大鼠,断头取血后用酶免法测大鼠血清中TNF-α、IL-1、IL-6的表达水平。结果:治疗组大鼠血清中的TNF-α、IL-1、IL-6水平均低于模型组,复方甘草酸苷对佐剂性关节炎大鼠血清中TNF-α、IL-1、IL-6表达均成抑制作用。结论:复方甘草酸苷可降低佐剂性关节炎大鼠血清中TNF-α、IL-1、IL-6的表达,对类风湿性关节炎的治疗具有一定的作用。
Objective: To study the effect of compound glycyrrhizin on the expression of TNF-α IL-1 and IL-6 in sera of adjuvant arthritis rats and explore the therapeutic effect of compound glycyrrhizin on adjuvant arthritis. METHODS: Animal models of rheumatoid arthritis (AA) were established by subcutaneous injection of complete Freund’s adjuvant (CFA) into the right posterior plantar region of rats. Secondary arthritis occurred in rats 14 days after inflammation. The rats in the treatment group were given intraperitoneal injection of compound glycyrrhizin injection 2mg / kg for 10 days continuously until the 28th day. All the rats were sacrificed and the serum levels of TNF-α and IL- 1, IL-6 expression levels. Results: The serum levels of TNF-α, IL-1 and IL-6 in the treatment group were lower than those in the untreated group. Compound glycyrrhizin had no effect on the serum levels of TNF-α, IL-1 and IL in the adjuvant arthritis rats -6 expression were inhibited. Conclusion: Compound glycyrrhizin can reduce the expression of TNF-α, IL-1 and IL-6 in the serum of adjuvant arthritis rats, and has a certain effect on the treatment of rheumatoid arthritis.