p53基因是一种抑瘤基因(TSG),p53基因的突变在人恶性肿瘤中常见.其突变可造成错误的蛋白表达,这种蛋白与正常蛋白相比具有更强的代谢稳定性,在细胞核中沉积,可达到能用免疫组织化学方法检出的阈值.这样,免疫组织化学方法检出其蛋白产物就可以作为p53基因突变的一个指征.本实验检测p53蛋白在中枢神经系统肿瘤中的表达,并研究了其与增生相关抗原PCNA(增殖细胞核抗原)的关 The p53 gene is a tumor suppressor gene (TSG). Mutations in the p53 gene are common in human malignancies. Mutations can cause erroneous protein expression. This protein is more metabolically stable than the normal protein in the nucleus. Sedimentation in the medium can be achieved using immunohistochemical detection thresholds. In this way, immunohistochemical detection of its protein product can serve as an indicator of p53 gene mutation. This experiment examined the p53 protein in tumors of the central nervous system. Expression and study of its association with the proliferation-associated antigen PCNA (proliferating cell nuclear antigen)