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目的：观察脑康复冲剂对血瘀证动物模型体内血栓、体外血栓的作用及对血液流变性的影响，探讨脑康复冲剂预防脑血栓形成药效学机理。方法：兔、大鼠预防性给药，观察脑康复冲剂对兔实验性体外血栓及血液流变性的影响；对大鼠体内血栓的影响。结果：用高分子右旋糖苷造成血瘀证动物模型，表现为血液粘度升高，红细胞聚集性增强等，脑康复冲剂具有抑制体外血栓形成、延长体内血栓形成时间的作用，并能降低动物的血液粘度、抑制血小板的聚集性。结论：脑康复冲剂具有活血化瘀、拮抗血栓形成的功效，其作用机理与降低血小板聚集，改善血液流动状况，防治动物微循环障碍有关。
Objective: To observe the effect of Naoxingan granule on blood clots and extracorporeal thrombus in animal models of blood stasis syndrome and its influence on hemorheology, and to explore the pharmacodynamic mechanism of Nao kang granules for preventing cerebral thrombosis. METHODS: Rabbits and rats were given prophylaxis. The effects of Nao kang granules on experimental thrombosis and hemorheology in rabbits were observed. The effect of thrombosis in rats was also observed. RESULTS: The animal model of blood stasis syndrome was caused by high molecular dextran, which showed increased blood viscosity and enhanced red blood cell aggregation. Nao kang granules had the effect of inhibiting thrombosis in vitro and prolonging thrombus formation time in vivo, and could reduce the animal’s Blood viscosity, platelet aggregation inhibition. Conclusion: Naoaofu Granule has the effect of promoting blood circulation and removing blood stasis and antagonizing thrombosis. The mechanism is related to reducing platelet aggregation, improving blood flow and preventing microcirculation in animals.