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目的观察阴道用乳杆菌活菌胶囊(定君生)治疗妊娠中晚期和产褥期细菌性阴道病的临床疗效以及妊娠中晚期干预细菌性阴道病对围产结局的影响。方法选取2014年1月-12月在我院门诊就诊的妊娠中晚期BV患者160例,根据患者自愿将其分为治疗组96例和未治疗组64例,治疗组给予定君生处理,观察治疗效果并随访治疗组与未治疗组的围产结局。选取2014年1月-12月在我院门诊就诊的产褥期BV患者100例,随机分为观察组50例和对照组50例,观察组给予定君生处理,对照组给予甲硝唑栓处理,比较两组临床疗效、过氧化氢浓度及复发情况。结果妊娠中晚期BV治疗组治愈56例,有效30例,总有效率89.6%,BV治疗组孕妇流产、早产、胎膜早破、低出生体质量儿、新生儿感染和产褥感染的发生率低于BV未治疗组,差异有统计学意义(χ2=14.127,P<0.05)。产褥期BV观察组总有效率为88%,对照组总有效率82.0%,差异没有统计学意义(χ2=0.706,P>0.05);观察组和对照组乳杆菌定植成功率分别为86.0%和68.0%,差异有统计学意义(χ2=4.574,P<0.05);30d后随访观察组复发率为11.4%,对照组复发率为31.7%,差异有统计学意义(χ2=5.262,P<0.05)。结论妊娠中晚期BV经过定君生治疗后能改善围产结局,定君生治疗妊娠中晚期及产褥期BV,安全有效并能减少复发。
Objective To observe the clinical efficacy of live vaginal Lactobacillus capsule (Ding Junsheng) in the treatment of bacterial vaginosis in the second and third trimester of pregnancy and the effect of bacterial vaginosis during the second trimester on perinatal outcome. Methods A total of 160 middle-and late-stage BV patients from January 2014 to December 2014 in our hospital were selected and divided into treatment group (96 cases) and untreated group (64 cases). Patients in treatment group were treated with Ding Jun Sheng Treatment effect and follow-up treatment group and untreated group perinatal outcome. 100 cases of puerperium BV patients who were treated in our hospital from January to December 2014 were randomly divided into observation group (50 cases) and control group (50 cases). The observation group was given Ding Jun Sheng treatment while the control group was treated with metronidazole suppository. The clinical efficacy, hydrogen peroxide concentration and recurrence were compared between the two groups. Results In the second and third trimester of pregnancy, 56 cases were cured, 30 cases were effective and the total effective rate was 89.6%. The incidence of miscarriage, premature labor, premature rupture of membranes, low birth weight, neonatal infection and puerperal infection in BV group Lower than BV untreated group, the difference was statistically significant (χ2 = 14.127, P <0.05). The total effective rate was 88% in the observation group and 82.0% in the control group, the difference was not statistically significant (χ2 = 0.706, P> 0.05). The success rates of Lactobacillus colonization in the observation group and control group were 86.0% and 68.0% %, The difference was statistically significant (χ2 = 4.574, P <0.05); after 30 days, the recurrence rate was 11.4% in the observation group and 31.7% in the control group, the difference was statistically significant (χ2 = 5.262, . Conclusions BV in middle and late gestation can improve perinatal outcome after Ding Jun Sheng treatment. Ding Jun Sheng is safe and effective in treating middle and late pregnancy and puerperium BV, and can reduce recurrence.