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大骨节病(KBD)患者有软骨硫酸软骨素代谢障碍。应用KBD区粮饲养大鼠也见到有类似的硫代谢改变。为探索KBD硫代谢障碍的机理,我们曾检查KBD萝验大鼠血液中促进软骨至白多糖硫酸化作用的硫酸化因子(S·F)的活性。结果表明KBD病区粮饲养的大鼠血清S·F活性明显低于非病区粮对照组。
Kashin-Beck disease (KBD) patients have cartilage chondroitin metabolism disorders. Similar diets of sulfur metabolism were also seen in rats fed KBD diets. To explore the mechanism of KBD dysfunctions, we examined the activity of the sulfated factor (S · F) in the blood of KBD rats to promote cartilage-to-polysaccharide sulfation. The results showed that the serum S · F activity of food-fed rats in KBD ward was significantly lower than that of non-ward food control group.