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为探讨肝癌肿瘤浸润淋巴细胞（ＴＩＬ）杀伤肝癌细胞的作用机制，用透射电镜观察了ＴＩＬ与肝癌细胞共同培养后，ＴＩＬ吸附、包绕和吞噬自体和ＥＢＬ－７４０２肝癌细胞，促使肝癌细胞凋亡。接受ＴＩＬ治疗的肝癌术后患者，外周血单个核细胞（ＰＢＭＣ）产生干扰素（ＩＦＮγ）活性和血清肿瘤坏死因子（ＴＮＦ－α）活性，明显高于手术对照组。与单纯手术治疗组比较，ＴＩＬ组生存时间明显延长。肝癌术后应用ＴＩＬ的疗效显著优于单纯手术治疗，可望为肝癌的综合治疗提供新的方法。
To investigate the mechanism of tumor-infiltrating lymphocytes (TIL) killing hepatocellular carcinoma cells in liver cancer, TIL was co-cultured with hepatoma cells using transmission electron microscopy. TIL adsorbed, entrapped and engulfed autologous and EBL-7402 hepatocellular carcinoma cells to promote apoptosis of hepatoma cells. . In patients undergoing hepatocellular carcinoma after TIL treatment, peripheral blood mononuclear cells (PBMCs) produced interferon (IFNγ) activity and serum tumor necrosis factor (TNF-α) activity, which was significantly higher than that of the surgical control group. Compared with the surgery alone group, the survival time was significantly longer in the TIL group. The therapeutic effect of TIL after hepatocellular carcinoma surgery is significantly better than that of surgery alone, and it is expected to provide a new method for the comprehensive treatment of liver cancer.