局麻药应用于临床,已经整一个世纪了。今天,我们回顾一下局麻药及其中毒预防观的辩证发展过程,为临床用药提供坚实的理论基础,不无裨益。一、局麻药的发现与发展 1885年Gaedike从古柯叶中提出Erythroxylin。1860年,澳大利亚化学家Albert Niemann从Erythroxylin中提纯出可卡因(Cocaine),并发现其晶体可使他的舌头麻木。1868年秘鲁外科医生Thomas Morenoy Maiz发表了专题文 Local anesthetic used in clinical, it has been a whole century. Today, we review the dialectical development of local anesthetics and their concept of poisoning prevention and provide a solid theoretical basis for clinical drug use. First, the discovery and development of local anesthetic 1885 Gaedike Erythroxylin from coca leaf. In 1860, Australian chemist Albert Niemann purified Cocaine from Erythroxylin and found that his crystals numb the tongue. 1868 Peruvian surgeon Thomas Morenoy Maiz published a feature article