近日,来自芝加哥大学的研究人员将他们的最新研究成果在线发表在了Nature杂志上。他们发现,黑色素瘤细胞可以通过产生大量的beta-catenin,从而将它们自己与免疫系统的抗癌前线武器-T细胞屏蔽。他们还发现beta-catenin是如何阻止T细胞浸润到肿瘤细胞,从而减弱免疫治疗效果的。最后,研究人员们提出建议,该如何绕开这个障碍。 Recently, researchers from the University of Chicago posted their latest research online in Nature. They found that melanoma cells can shield themselves from the immune system’s anticancer front-line weapon, T-cells, by producing large amounts of beta-catenin. They also found out how beta-catenin prevents T cells from infiltrating tumor cells, thereby weakening the immune response. Finally, the researchers make suggestions on how to get around this obstacle.