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Objective:To explore the density and mature status of Dendritic cell(DC) in cervical cancer and correlation with the expression of transforming growth factor-beta 1(TGF-β1).Methods:Streptavidin-peroxidase(SP) immunohistochemistry methods were used to detect S-100 DC and the expression of TGF-β1 in 20 normal cervical tissues and 53 cervical cancer tissues without any sort of chemotherapy or radiation therapy prior to resection.Medical records were reviewed,clinicopathological variables were retrieved and used for analysis.Results:Two types of DC were observed under the microscope.The expression of DC in cervical cancer was significantly higher than that in normal tissues(23.34 cells/mm~2 vs 29.91 cells/mm~2,P<0.05),and significantly higher in early stage than that in advanced stage(P<0.05).The expression of TGF-β1 was significantly higher in cervical cancer than that in normal tissues (P<0.025).However,there was no correaction between TGF-β1 and lymph nodes metastasis.The index of DC in cervical cancer was negatively correlated to the expression of TGF-β1 in tumor cells (r=-0.8875,P=0.0001).Conclusion:Maturation of DC in cervical cancer is inhibited.The decreased number of DC and the higher expression of TGF-β1 are due to the failure of the immunity,these may play an important role in the development of the cervical cancer.
Objective: To explore the density and mature status of Dendritic cell (DC) in cervical cancer and correlation with the expression of transforming growth factor-beta 1 (TGF-β1). Methods: Streptavidin-peroxidase (SP) immunohistochemistry methods were used to detect S-100 DC and the expression of TGF-β1 in 20 normal cervical tissues and 53 cervical cancer tissues without any sort of chemotherapy or radiation therapy prior to resection. Medical records were reviewed, clinicopathological variables were retrieved and used for analysis. Results: Two Types of DC were observed under the microscope. The expression of DC in cervical cancer was significantly higher than that in normal tissues (23.34 cells / mm ~ 2 vs. 29.91 cells / mm ~ 2, P <0.05), and significantly higher in early stage than that in advanced stage (P <0.05). The expression of TGF-β1 was significantly higher in cervical cancer than that in normal tissues (P <0.025) .However, there was no correaction between TGF-β1 and lymph node metastasis. index of D C in cervical cancer was negatively correlated to the expression of TGF-β1 in tumor cells (r = -0.8875, P = 0.0001) .Conclusion: Maturation of DC in cervical cancer is inhibited. The decreased number of DC and the higher expression of TGF -β1 are due to the failure of the immunity, these may play an important role in the development of the cervical cancer.