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高效抗逆转录病毒治疗法(HAART)应用临床以来,大大降低了AIDS病的死亡率,使获得性免疫缺陷综合症AIDS病从“绝症”变为1种可控的慢性疾病。但HAART治疗也面临着不能彻底清除患者体内的AIDS病毒(HIV)、耐药及较多ADR等问题。因此,如何合理使用抗HIV药物,是AIDS治疗中面临的问题。该文从循证药学的角度,探讨了抗HIV药物有效性、耐药性和安全性及药物经济学,以期为临床合理用药提供参考。
Since the clinical application of HAART, the mortality rate of AIDS has been greatly reduced and the AIDS-Acquired Immune Deficiency Syndrome (AIDS) disease has been changed from “terminal illness ” to a controlled and chronic disease. But HAART treatment also faces the problem of not completely eliminating the AIDS virus (HIV), drug resistance and more ADR in patients. Therefore, how to use anti-HIV drugs reasonably is a problem in AIDS treatment. From the perspective of evidence-based pharmacy, the article discusses the effectiveness, drug resistance and safety of anti-HIV drugs and the economics of pharmacy, in order to provide a reference for clinical rational drug use.