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目的 :研究凋亡细胞对T细胞活化的影响。方法 :以ConA刺激小鼠脾细胞增殖体系为研究对象 ,观察凋亡细胞预处理后对ConA刺激的脾细胞CD6 9表达的影响。结果 :凋亡细胞可以抑制T细胞活化 ,而活细胞或坏死细胞却不能 ,同时抑制效果与凋亡种类及凋亡诱导方式无关 ,而与凋亡细胞数量密切相关。结论 :研究证明了凋亡细胞可以主动抑制T细胞活化 ,这一发现拓宽了目前对凋亡的认识 ,表明凋亡细胞主动调节免疫反应在一些生命的基本现象和一些疾病中有重要意义。
Objective: To study the effect of apoptotic cells on T cell activation. Methods: ConA-stimulated mouse spleen cell proliferation system as the research object, to observe the apoptotic cells after pretreatment ConA-stimulated splenocyte CD6 9 expression. Results: Apoptotic cells could inhibit the activation of T cells, but the viable cells or necrotic cells could not. At the same time, the inhibitory effect was not related to the type of apoptosis and the induction of apoptosis, but closely related to the number of apoptotic cells. CONCLUSIONS: Studies have shown that apoptotic cells can actively inhibit T cell activation. This discovery broadens the current understanding of apoptosis, suggesting that the apoptotic cells actively regulate immune responses are important in some life-based phenomena and in some diseases.