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5-单硝酸异山梨醇(IS-5-MN)是二硝异酸山梨醇的活性代谢产物。一般认为IS-5-MN的最低血浆浓度<95ng/ml是防止二硝酸异山梨醇和IS-5-MN耐受性形成的必要条件。本试验按照双盲、交叉和安慰剂
Isosorbide-5-mononitrate (IS-5-MN) is the active metabolite of dinitratedosorbide. It is generally believed that the minimum plasma concentration of IS-5-MN <95 ng / ml is a necessary condition to prevent the formation of isosorbide dinitrate and IS-5-MN tolerance. The trial followed double-blind, crossover and placebo