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目的 了解核工业超剂量受照人员的健康状况 ,探求辐射危害所致早期改变指标。方法 采用现场调查与实验室细胞遗传学和体细胞基因位点突变检测相结合的方法 ,对核工业某厂 5 0名超剂量受照人员和 5 0名对照人员进行调查。结果 染色体畸变率 (CA)、微核形成率 (MN)和HPRT(次黄嘌呤鸟嘌呤磷酸核糖转移酶 )基因位点突变频率(HPRT)超剂量组均高于对照组 ,其中CA和HPRT结果两组之间存在统计学显著差异。超剂量组中堆工作业岗位的三项指标均明显高于放化工作业岗位的结果 ,各项指标随着累积剂量的增高而增高 ,与剂量之间可拟合Lg直线回归方程。结论 各项指标综合分析 ,可对群体或个体早期或近期的辐射损伤危害作出评价
Objective To understand the health status of over-dosed workers in the nuclear industry and explore early changes in radiation hazards. Methods A total of 50 overdosed workers and 50 control personnel from a nuclear industry plant were investigated by using field investigations in combination with laboratory cytogenetics and somatic gene mutation detection. Results The rate of chromosomal aberration (CA), micronucleus formation (MN) and HPRT (hypoxanthine guanine phosphoribosyl transferase) gene locus mutation frequencies (HPRT) were higher in the overdose group than in the control group, with CA and HPRT results. There was a statistically significant difference between the two groups. The three indicators of the heap job position in the overdose group were significantly higher than those in the chemical engineering job position. The indicators increased as the cumulative dose increased, and the Lg linear regression equation was fitted to the dose. Conclusion Comprehensive analysis of various indicators can evaluate the early or recent radiation damage hazards of groups or individuals.