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目的 :探讨罕见的艾萨克 (Isaacs)综合征的临床特点、诊断及治疗方法。方法 :分析 3例艾萨克综合征临床表现、肌电图特点及治疗预后。结果 :3例均为青壮年女性 ,主要表现为自发性连续性肌肉颤搐 ,睡眠不消失 ,均伴多汗。肌电图发现持续的自发运动电位发放。卡马西平控制症状较好 ,免疫治疗有效。结论 :本综合征可能在女性中多见 ,颤搐表现结合肌电图是诊断关键 ,控制症状时用卡马西平可能优于苯妥英钠 ,并需进行免疫治疗
Objective: To investigate the clinical features, diagnosis and treatment of rare Isaacs syndrome. Methods: The clinical manifestations, EMG characteristics and prognosis of 3 patients with Isaac’s syndrome were analyzed. Results: All the 3 cases were young and middle-aged women. The main manifestations were spontaneous and continuous muscle twitching without sleep disappearance, accompanied by hyperhidrosis. EMG found sustained spontaneous motor potential release. Carbamazepine control the symptoms better, effective immunotherapy. Conclusion: The syndrome may be more common in women, twitch performance combined with EMG is the key to diagnosis, control of symptoms with carbamazepine may be superior to phenytoin sodium, and the need for immunotherapy