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目的:观察祛斑养阴颗粒剂对不同疾病活动度系统性红斑狼疮(SLE)患者疾病控制及生存质量(QOL)的影响。方法:将136例SLE患者按SLEDA评分标准随机分为4组,Ⅰ组病情基本无活动,Ⅱ组轻度活动,Ⅲ组中度活动,Ⅳ组重度活动。分别予祛斑养阴颗粒剂联合西药常规方案治疗,经治疗1个月、3个月后分别对患者疾病活动度及生存质量方面的改善情况进行分析。结果:经治疗后,各组SLEDAI评分较治疗前明显降低(P<0.05)。各组生存质量各维度得分均有不同程度的升高,且在总体健康感、生命活力、躯体功能上,与治疗前比,有显著差异(P<0.05);Ⅰ组、Ⅱ组及Ⅲ组在总体评分上较治疗前明显升高,差异有显著意义(P<0.05);Ⅳ组总体评分较治疗前升高,差异无统计学意义(P>0.05)。结论:祛斑养阴颗粒剂结合西药对稳定病情起协同作用,能有效的治疗SLE,更好控制疾病,提高SLE患者QOL。
Objective: To observe the effect of Qumei Yangyin Granules on disease control and quality of life (QOL) in patients with SLE with different disease activities. Methods: Thirty-six patients with SLE were randomly divided into 4 groups according to the standard of SLEDA. The patients in group Ⅰ had no activity at all, mild activity in group Ⅱ, moderate activity in group Ⅲ and severe activity in group Ⅳ. Respectively freckle Yangyin Granules combined with conventional Western medicine treatment, the treatment of 1 month, 3 months after the patient’s disease activity and quality of life to improve the situation were analyzed. Results: After treatment, the SLEDAI score of each group was significantly lower than that before treatment (P <0.05). There were significant differences in scores of all dimensions of quality of life (P <0.05) in all dimensions of quality of life (P <0.05), and there were significant differences in overall health, vitality and physical function between before and after treatment The overall score was significantly higher than that before treatment, the difference was significant (P <0.05). The overall score in group Ⅳ was higher than that before treatment, with no significant difference (P> 0.05). Conclusion: Freckle Yangyin Granules combined with western medicine play a synergistic role in the stability of the disease, which can effectively treat SLE, better control the disease and improve the QOL of SLE patients.