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为了研究左卡尼汀(L-carnitine,LC)对D-半乳糖所致衰老小鼠的抗氧化作用,试验将50只小鼠随机分成5组,即空白对照组、模型组和左卡尼汀治疗组[0.25、0.50、1.00 g/(kg.d)],采用D-半乳糖复制亚急性衰老小鼠模型,试验6周后处死小鼠,测定其血浆、脑组织及肝脏中的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及丙二醛(MDA)含量。试验结果显示,左卡尼汀能显著提高衰老小鼠血清、脑组织及肝脏中的SOD、GSH-Px活性,降低MDA含量,且呈剂量依赖性。表明左卡尼汀有一定的抗衰老作用,其机制可能与抗氧化作用有关。
In order to study the anti-oxidative effects of L-carnitine (LC) on aging mice induced by D-galactose, 50 mice were randomly divided into 5 groups: blank control group, model group and leucani (0.25,0.50,1.00 g / (kg · d)], D-galactose-induced subacute aging mouse model, 6 weeks after the test mice were sacrificed to determine the plasma, brain tissue and liver in super (SOD), glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) content. The results showed that L-carnitine can significantly increase the activity of SOD and GSH-Px in serum, brain tissue and liver of aging mice and decrease the MDA content in a dose-dependent manner. L-carnitine shows that there is a certain anti-aging effect, the mechanism may be related to antioxidant effects.