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目的:探讨老年女性2型糖尿病患者高血压与骨质疏松(osteoporosis,OP)、骨密度(bone mineral density,BMD)的关系。方法:将179例老年女性T2DM患者分为2组,高血压组124例,非高血压组55例。测量腰椎和髋部的BMD。χ2检验比较2组总OP、腰椎OP、髋部OP的患病率,协方差分析各部位BMD的差别,并用二元logistic逐步回归方法分析OP与相关危险因素之间的相关性。结果:非高血压组总OP、腰椎OP、髋部OP的患病率均高于高血压组(P值分别为P总=0.037、P腰=0.042、P髋=0.051)。2组BMD比较,高血压组各部位的BMD均高于非高血压组,其中L3、L4BMD差异有统计学意义(P值分别为P3=0.040,P4=0.021)。但在校正体质量指数(body mass index,BMI)后P值均明显增大,2组BMD均无统计学差异,在校正C肽后P值也变大,但无校正BMI后P值变化明显。应用二元Logistic回归方法进行分析,年龄、BMI、骨钙素与OP有关,而高血压与OP无明显的相关。结论:OP与年龄、BMI、骨钙素有关,而高血压与OP之间没有必然的联系。
Objective: To investigate the relationship between hypertension and osteoporosis (OP) and bone mineral density (BMD) in elderly women with type 2 diabetes mellitus. Methods: 179 elderly women with T2DM were divided into two groups: 124 in hypertensive group and 55 in non-hypertensive group. Measure BMD of lumbar spine and hip. Chi-square test was used to compare the prevalence of OP, lumbar OP and hip OP in two groups, and the differences of BMD between different groups were analyzed by covariance. The correlation between OP and related risk factors was analyzed by binary logistic regression analysis. Results: The prevalences of OP, lumbar OP and hip OP in non-hypertension group were higher than those in hypertension group (P = 0.037, P = 0.042, P = 0.051). Compared with non-hypertension group, the BMD of each group in hypertension group was significantly higher than that of non-hypertension group (P = 0.040, P = 0.021). However, P values increased significantly after body mass index (BMI) correction, but there was no significant difference between the two groups in BMD and P values after C-peptide correction. However, P values did not change significantly after BMI correction . Binary Logistic regression analysis was used to analyze age, BMI, osteocalcin and OP, but no significant correlation between hypertension and OP. Conclusion: OP is related to age, BMI and osteocalcin, but there is no necessary relationship between hypertension and OP.