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本文测定了我所合成的前列腺素合成酶抑制剂(PGSI)DPE_(10_)和DPE_(12)对豚鼠离体子宫肌条收缩的影响。结果表明,DPE_(10)和DPE_(12)与经典的PGSI消炎痛和萘普生一样,对花生四烯酸所致子宫收缩活动均有抑制作用,其中对子宫肌的收缩频率及张力的抑制尤为明显。4种化合物的作用强度大致相当。此外,还观察了DPE_(10)和DPE_(12)对15-甲基-PGF_(2α)对马来酸麦角新碱所致的豚鼠子宫肌条收缩的影响,证明两化合物不能对抗二药对肌条的兴奋作用。
In this article, we measured the effects of the prostaglandin synthase inhibitors (PGSI) DPE_(10_) and DPE_(12) which were synthesized on the contraction of isolated uterine muscle strips in guinea pigs. The results showed that DPE_(10) and DPE_(12), like classical PGSI indomethacin and naproxen, inhibited the uterine contractile activity induced by arachidonic acid, and inhibited the contraction frequency and tension of uterine muscle. Especially obvious. The effects of the four compounds are roughly equivalent. In addition, the effect of DPE_(10) and DPE_(12) on the contraction of guinea pig uterine muscle strips induced by ergonovine maleate was also observed. It was proved that the two compounds could not counteract the two drug pairs. The excitatory effect of muscle strips.