随着广谱抗菌素的应用,真菌性二重感染日益增多,机体免疫功能的降低(包括免疫抑制剂的应用等)或某些医疗手术都可导致真菌病的发生。全身性真菌感染(深部真菌病)现已成为严重的并几乎难以解决的治疗问题。两性霉素 B 是个高效的广谱抗真菌药物,但须静脉注射给药且副作用太大,尤其是对肾脏的毒性,故必须审慎使用。其它多烯类 With the application of broad-spectrum antibiotics, fungal double infections are increasing day by day. The decrease of immune function (including the application of immunosuppressive agents) and some medical operations can lead to fungal diseases. Systemic fungal infections (deep mycosis) have now become serious and almost intractable treatment problems. Amphotericin B is a highly effective broad-spectrum antifungal drug, but it must be administered intravenously and has side effects that are particularly toxic to the kidneys and must be used with caution. Other polyenes