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目的观察健脾化湿颗粒对脾虚型肠易激综合征(Irritable Bowel Syndrome,IBS)模型大鼠小肠运动的影响。方法采用束缚应激刺激2周加灌服番泻叶煎剂的方法造成脾虚型肠易激综合征大鼠模型;通过测量小肠碳末推进率和离体肠管的振幅、频率来分析健脾化湿颗粒对脾虚型肠易激综合征模型大鼠小肠运动的影响。结果模型组大鼠小肠运动明显加快,经健脾化湿颗粒治疗后显著减慢(P<0.05)。结论中、高剂量健脾化湿颗粒可显著改善大鼠的腹泻症状,减慢小肠运动,改善IBS症状。
Objective To observe the effect of Jianpi Huashi Granule on small intestine movement in rats with Irritable Bowel Syndrome (IBS). Methods The rat model of irritable bowel syndrome with spleen deficiency was induced by restraint stress for 2 weeks plus gavage senna decoction. The spleen deficiency was measured by measuring the propulsion rate of small intestine and the amplitude and frequency of isolated intestine. Effect of Wet Granules on Intestinal Movement in Rats with Irritable Bowel Syndrome of Spleen Deficiency Syndrome . Results The intestinal movement of the rats in the model group was significantly accelerated and significantly slowed after treatment with Jianpi Huashi Granule (P<0.05). Conclusion The moderate and high dose of Jianpi Hushui Granules can significantly improve the symptoms of diarrhea in rats, slow down the movement of the small intestine and improve the symptoms of IBS.