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目的探讨长效长方案促排卵周期中,冲洗卵泡对患者胚胎发育情况影响。方法回顾性分析2014年7月~2016年6月在广东医科大学附属医院生殖中心接受长效长方案试管婴儿(IVF)助孕的343例女性的临床资料,其中采用卵泡冲洗99例(冲洗组),采用直接吸取卵泡液244例(对照组)。对两组患者获卵率、正常受精(2PN)卵率、2PN卵裂率、优胚率、囊胚率、胚胎可利用率、临床妊娠率、着床率和流产率进行分析。结果在长效长方案促排卵周期中,冲洗组的卵裂胚胎利用率、优胚率、囊胚冷冻率均显著高于对照组,差异有统计学意义(P<0.05),其他实验室和临床各项指标间差异无统计学意义(P>0.05)。结论在长效长方案促排卵周期中,冲洗卵泡并不能使获卵率增加,但能有效提高卵裂胚胎的利用率,优胚率和囊胚冷冻率,患者临床妊娠率和种植率均有增高趋势。
Objective To investigate the effect of flushing follicles on the development of embryos during the long-term and long-term ovulation induction cycles. Methods The clinical data of 343 women who underwent long-term IVF-assisted pregnancy in the Reproductive Center of Guangdong Medical University Hospital from July 2014 to June 2016 were retrospectively analyzed. Among them, 99 cases were treated by follicle irrigation ), Using direct drawing follicular fluid in 244 cases (control group). Oviposition rate, normal fertilization (2PN), 2PN cleavage rate, excellent embryo rate, blastocyst rate, embryo availability rate, clinical pregnancy rate, implantation rate and abortion rate were analyzed. Results In the long-term long-term ovulation induction schedule, the cleavage embryo utilization rate, excellent embryo rate and blastocyst freezing rate in the rinse group were significantly higher than those in the control group (P <0.05). Other laboratories and There was no significant difference between clinical indicators (P> 0.05). Conclusion In the long-term ovulation induction schedule, follicles can not increase the rate of ovulation, but can effectively improve the utilization of cleavage embryos, excellent embryo rate and blastocyst freezing rate, the clinical pregnancy rate and implantation rate of patients have Increase the trend.