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MicroRNA(miRNA)是一类由内源基因编码的长度为18～24个核苷酸的非编码单链RNA分子。miRNA参与生命过程中一系列的重要进程,包括细胞增殖、分化和凋亡,个体发育,机体代谢及免疫调节。目前已发现的人类miRNA(约50%)在基因组上定位于肿瘤相关基因的脆性位点。根据miRNA与靶基因的配对程度,将miRNA与靶基因的作用方式主要分为两种:完全配对和不完全配对。Wakiyama等
MicroRNAs (miRNAs) are a class of non-coding single-stranded RNA molecules of 18 to 24 nucleotides in length encoded by endogenous genes. MiRNAs are involved in a series of important processes in the life process, including cell proliferation, differentiation and apoptosis, individual development, body metabolism and immune regulation. So far, human miRNAs (about 50%) have been found to be located on the genome at the fragile sites of tumor-associated genes. According to the degree of pairing between the miRNA and the target gene, the mode of action of the miRNA and the target gene can be mainly divided into two types: complete pairing and incomplete pairing. Wakiyama et al