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目的分析摩根摩根菌的临床分布特点及耐药现状,为抗感染治疗提供参考依据。方法对医院2013年7月-2015年6月临床分离的80株摩根摩根菌的来源与耐药性进行回顾性分析,并对痰液标本与其他类型标本分离到的摩根摩根菌对抗菌药物的耐药情况进行统计学比较。结果多种临床标本均可分离到摩根摩根菌,以痰液标本居多,占58.75%;科室分布以ICU为主,占41.25%,其次为急诊内科,占31.25%。20种抗菌药物中,敏感性较高的药物为丁胺卡那霉素(98.75%)、头孢吡肟(91.25%)、氨曲南(87.50%)、亚胺培南(86.25%);痰液标本与其他标本分离到的摩根摩根菌对头孢哌酮/舒巴坦、头孢他啶、头孢曲松、头孢吡肟、厄他培南、亚胺培南、庆大霉素、环丙沙星、复方新诺明等9种抗菌药物有显著性差异(P<0.05)。其他标本分离到的摩根摩根菌对此9种药物的敏感性要显著高于痰液标本分离到的摩根摩根菌。结论对摩根摩根菌引起的感染应合理使用抗菌药物早期治疗,避免耐药菌株的产生;不同部位的摩根摩根菌感染应选用不同种抗菌药物,以提高治疗效果。
Objective To analyze the clinical distribution characteristics and drug resistance status of Morganella morganii and provide a reference for anti-infection treatment. Methods A retrospective analysis was made on the sources and drug resistance of 80 Morganella morganii isolates from July 2013 to June 2015 in the hospital. Morganella morganii isolated from sputum samples and other types of specimens was analyzed for its antimicrobial activity Drug resistance were statistically compared. Results Morganella morganii was isolated from a variety of clinical specimens, accounting for 58.75% of the total sputum specimens, accounting for 41.25% of the total number of ICUs, followed by emergency medicine, accounting for 31.25%. Of the 20 antimicrobial agents, the more sensitive drugs were amikacin (98.75%), cefepime (91.25%), aztreonam (87.50%) and imipenem (86.25%); sputum Morganella morganii isolated from fluid samples and other specimens showed good resistance to cefoperazone / sulbactam, ceftazidime, ceftriaxone, cefepime, ertapenem, imipenem, gentamycin, ciprofloxacin, There were significant differences (P <0.05) among the 9 antibacterials such as cotrimoxazole. Morganella morganii isolates from other specimens were significantly more sensitive to the nine drugs than those isolated from sputum samples. Conclusion Infection caused by Morganella Morganella should be treated with antibacterials early to avoid the emergence of drug-resistant strains. Different genus Morganella should be treated with different kinds of antimicrobial agents to improve the therapeutic effect.