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目的:探讨脓毒症早期血乳酸清除率检测的临床意义。方法:对2011年10月至2013年6月ICU收治的脓毒症患者63例分为存活组和死亡组,高、低乳酸清除率组,测定入组时(0 h)及入组后6 h、24 h的动脉血乳酸水平及6 h、24 h乳酸清除率,入住ICU后24 h的APACHEⅡ评分、48 h的器官衰竭数目及28 d内死亡率,比较存活组和死亡组,高、低乳酸清除率组间的差异。结果:存活组的6 h乳酸清除率高于死亡组(P<0.05);高乳酸清除率组的24 h APACHEⅡ评分、48 h器官衰竭数目及28 d内死亡率均明显低于低乳酸清除率组(P<0.05)。结论:早期血乳酸清除率可指导脓毒症的治疗及评估其预后。
Objective: To investigate the clinical significance of detection of early lactate clearance rate in sepsis. Methods: Sixty-three patients with sepsis admitted to the ICU from October 2011 to June 2013 were divided into survival group, death group, high and low lactic acid clearance group, arterial blood lactate levels at 24 h, 6 h, 24 h lactic acid clearance rate, 24 h APACHE Ⅱ score after admission to ICU, 48 h organ failure and 28 d mortality, survival and death groups, Low lactic acid clearance differences between groups. Results: The 6 h lactic acid clearance rate in survival group was higher than that in death group (P <0.05). The 24 h APACHE II score, 48 h organ failure rate and 28 d mortality rate in high lactic acid clearance group were significantly lower than those in low lactic acid clearance rate Group (P <0.05). Conclusion: Early lactate clearance may guide the treatment of sepsis and assess its prognosis.