用ｐ５３单克隆抗体，对１１７例胃癌和非癌组织的石蜡切片及５株胃癌细胞，进行了免疫组化研究。结果５６例进展期胃癌阳性核染２１例，４例早期胃癌无一例阳性，非癌组织均为阴性；５株胃癌细胞均显示阳性着色，通过ＦＡＣＳ分析，５株胃癌细胞均为非二倍体。说明ｐ５３突变主要在胃癌进展中起作用，可能提示癌肿恶性度高。 Immunohistochemistry was performed on paraffin sections of gastric cancer and non-cancerous tissues and five gastric cancer cells using p53 monoclonal antibody. Results There were 21 cases of advanced gastric cancer with positive nuclear staining in 56 cases, 4 cases of early gastric cancer were not positive, non-cancer tissues were negative; 5 gastric cancer cells showed positive staining, 5 gastric cancer cells were non-diploid by FACS analysis . This suggests that p53 mutations play a major role in the progression of gastric cancer and may indicate a high degree of malignancy.